PRO33 SECRETS

max in WT synaptoneurosomes, suggesting that Src signaling may very well be downregulated in KI synapses. Conversely, our capability to rescue SERT perform in KI midbrain synaptoneurosomes through the inhibition of FAK indicates elevated FAK signaling downstream on the Pro32Pro33 mutant, as confirmed by improved pFAK localization in 5-HT synapses.